SHORT COURSE TREATMENT OF VISCERAL LEISHMANIASIS WITH LIPOSOMAL AMPHOTERICIN B (AmBisome)

Davidson R., N; Di Martino, L; Gradoni, L; Giacchino, R; Gaeta, Gb; Pempinello, R; Scotti, S; Cascio, Antonio; Castagnola, E; Maisto, A; Gramiccia, M; Di Caprio, D.

We evaluated liposomal amphotericin B (AmBisome; Vestar, San Dimas, CA) administered to 88 immunocompetent patients (56 children) with visceral leishmaniasis (VL) caused by Leishmania infantum. Thirteen patients received 4 mg/kg on days 1-5 and 10 (total dose, 24 mg/kg), and all were cured; 42 received 3 mg/kg on days 1-5 and 10 (18 mg/kg), and 41 were cured; 32 received 3 mg/kg on days 1-4 and 10 (15 mg/kg), and 29 were cured (amastigotes were not cleared from 1 child, and 2 relapsed). One adult was cured with a total dose of 12mg/kg. The four children who were not cured received 3 mg/kg for 10 days; none had further relapses. There were no significant adverse events. For VL due to L. infantum, we recommended a total dose of AmBisome of > or = 20 mg/kg, given in > or = 5 doses of 3-4 mg/kg over > or = 10 days.

Titolo:	SHORT COURSE TREATMENT OF VISCERAL LEISHMANIASIS WITH LIPOSOMAL AMPHOTERICIN B (AmBisome)
Autori:	DAVIDSON R. N DI MARTINO L GRADONI L GIACCHINO R GAETA GB PEMPINELLO R SCOTTI S CASCIO, Antonio CASTAGNOLA E MAISTO A GRAMICCIA M DI CAPRIO D. mostra contributor esterni nascondi contributor esterni
Data di pubblicazione:	1996
Rivista:	CLINICAL INFECTIOUS DISEASES
Abstract:	We evaluated liposomal amphotericin B (AmBisome; Vestar, San Dimas, CA) administered to 88 immunocompetent patients (56 children) with visceral leishmaniasis (VL) caused by Leishmania infantum. Thirteen patients received 4 mg/kg on days 1-5 and 10 (total dose, 24 mg/kg), and all were cured; 42 received 3 mg/kg on days 1-5 and 10 (18 mg/kg), and 41 were cured; 32 received 3 mg/kg on days 1-4 and 10 (15 mg/kg), and 29 were cured (amastigotes were not cleared from 1 child, and 2 relapsed). One adult was cured with a total dose of 12mg/kg. The four children who were not cured received 3 mg/kg for 10 days; none had further relapses. There were no significant adverse events. For VL due to L. infantum, we recommended a total dose of AmBisome of > or = 20 mg/kg, given in > or = 5 doses of 3-4 mg/kg over > or = 10 days.
Handle:	http://hdl.handle.net/11570/12896
Appare nelle tipologie:	14.a.1 Articolo su rivista

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