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EnglishPhosphoroamidate derivatives of adenine and 5-fluorouracil N,O-nucleoside analogues have been synthesized as potential antiviral prodrugs. In particular, dimethoxyphenyl phosphates, linked via nitrogen to L-leucine methyl ester were studied. The synthesized compounds were also subjected to in vitro evaluation for their RT inhibition. Results show that phosphoroamidate derivatives, in comparison with their corresponding N,O-nucleosides, present a promising antiviral activity, though of micro-molar order.
| Titolo: | Phosphoroamidate derivatives of N,O-nucleosides as inhibitors of reverse transcriptase |
| Autori: | |
| Data di pubblicazione: | 2009 |
| Rivista: | |
| Abstract: | Phosphoroamidate derivatives of adenine and 5-fluorouracil N,O-nucleoside analogues have been synthesized as potential antiviral prodrugs. In particular, dimethoxyphenyl phosphates, linked via nitrogen to L-leucine methyl ester were studied. The synthesized compounds were also subjected to in vitro evaluation for their RT inhibition. Results show that phosphoroamidate derivatives, in comparison with their corresponding N,O-nucleosides, present a promising antiviral activity, though of micro-molar order. |
| Handle: | http://hdl.handle.net/11570/14176 |
| Appare nelle tipologie: | 14.a.1 Articolo su rivista |
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