The mammalian circadian timing system is composed of almost as many individual clocks as there are cells. Several studies have been addressed, in invertebrates and lower vertebrates, to the issue of circadian rhythms in peripheral tissues. These suggest evidence that circadian rhythms are driven by cell-autonomous circadian oscillators, often light sensitive. This review has attempted to clarify the discussion of circadian systems in mammals and the issue of multiple circadian oscillators in their body thus suggesting that circadian oscillation properties are not exclusive to neural tissue or cells.
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