CINECA IRIS Institutional Research Information System
IRIS è la soluzione IT che facilita la raccolta e la gestione dei dati relativi alle attività e ai prodotti della ricerca. Fornisce a ricercatori, amministratori e valutatori gli strumenti per monitorare i risultati della ricerca, aumentarne la visibilità e allocare in modo efficace le risorse disponibili.
EnglishA quantitative structure-activity relationship (QSAR) study was performed on a set of 49 negative allosteric modulators of AMPA receptor, acting as anticonvulsant agents, using multiple linear regression. The predictive ability of the resulting model was evaluated against a set of 12 compounds; the results showed good statistics in regression and revealed high correlation between anticonvulsant activity and some electrotopological descriptors
http://hdl.handle.net/11570/1581750| Titolo: | QSAR study of anticonvulsant negative allosteric modulators of the AMPA receptor |
| Autori interni: | DE LUCA, Laura BARRECA, Maria Letizia GITTO, Rosaria CHIMIRRI, Alba |
| Data di pubblicazione: | 2004 |
| Rivista: | JOURNAL OF MEDICINAL CHEMISTRY |
| Abstract: | A quantitative structure-activity relationship (QSAR) study was performed on a set of 49 negative allosteric modulators of AMPA receptor, acting as anticonvulsant agents, using multiple linear regression. The predictive ability of the resulting model was evaluated against a set of 12 compounds; the results showed good statistics in regression and revealed high correlation between anticonvulsant activity and some electrotopological descriptors |
| Handle: | http://hdl.handle.net/11570/1581750 |
| Appare nelle tipologie: | 14.a.1 Articolo su rivista |
File in questo prodotto:
Copyright © 2017