CD30 ligand (CD30L) and its receptor CD30 are members of the tumor necrosis factor (TNF) and TNF receptor superfamilies that play a major role in inflammation and immune regulation. This study shows that prophylactic treatment with anti-CD30L mAb markedly reduces both laboratory and histological signs of CAR-induced pleurisy. These data suggest involvement of CD30-mediated signals in acute immunoinflammatory pathways induced by CAR.
Prevention of carrageenan-induced pleurisy in mice by anti-CD30 ligand monoclonal antibody
DI PAOLA R;GENOVESE, TIZIANA;MACRI', Battesimo Consolato;CUZZOCREA, Salvatore;DI PAOLA, ROSANNA
2004-01-01
Abstract
CD30 ligand (CD30L) and its receptor CD30 are members of the tumor necrosis factor (TNF) and TNF receptor superfamilies that play a major role in inflammation and immune regulation. This study shows that prophylactic treatment with anti-CD30L mAb markedly reduces both laboratory and histological signs of CAR-induced pleurisy. These data suggest involvement of CD30-mediated signals in acute immunoinflammatory pathways induced by CAR.File in questo prodotto:
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