Two diorganotin(IV)–NANA complexes (NANA (1) = b-N-acetyl-Neuraminic Acid = 5-amino-3,5-dideoxy-D-glycero-b-D-galactononulosic acid) with formula Me2Sn(IV)NANA (2) and Bu2Sn(IV)NANA (3) were synthesized and characterized by 1H, 13C and 119Sn NMR spectroscopy, both in D2O and DMSO-d6 solutions. The experimental data in DMSO suggested the monosaccharide bidentate chelation via O1 carboxylate and vicinal O2 alkoxide atoms, which, in D2O, can be dynamically extended to a third binding site (O8 atom) of the pendant chain. Coordination at the tin atom is discussed on the basis of experimental NMR data and DFT calculation.
Solution structure of R2Sn(IV)-beta-N-acetyl-neuraminate (R = Me, Bu) complexes in D2O and DMSO-d(6): Experimental NMR and DFT computational study
ROTONDO, Archimede;ROTONDO, Enrico
2007-01-01
Abstract
Two diorganotin(IV)–NANA complexes (NANA (1) = b-N-acetyl-Neuraminic Acid = 5-amino-3,5-dideoxy-D-glycero-b-D-galactononulosic acid) with formula Me2Sn(IV)NANA (2) and Bu2Sn(IV)NANA (3) were synthesized and characterized by 1H, 13C and 119Sn NMR spectroscopy, both in D2O and DMSO-d6 solutions. The experimental data in DMSO suggested the monosaccharide bidentate chelation via O1 carboxylate and vicinal O2 alkoxide atoms, which, in D2O, can be dynamically extended to a third binding site (O8 atom) of the pendant chain. Coordination at the tin atom is discussed on the basis of experimental NMR data and DFT calculation.File in questo prodotto:
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