The interaction with DNA of the platinum(II) square planar complexes [Pt(N-N)(py)2]2+ (N-N ) = 1,10-phenanthroline (phen), dipyrido[3,2-d2’,3’-f]quinoxaline (dpq), dipyrido[3,2-a2’,3’-c]phenazine (dppz), benzodipyrido[b:3,2-h:2’3’ f]phenazine (bdppz)) has been investigated by means of absorption, circular and linear dichroism spectroscopy, DNA melting, and viscosity. In the presence of excess [DNA] all the complexes intercalate to the double helix. For those with the most extended phenanthrolines the binding mode depends on the [DNA]/[complex] ratio (q); at low q values the substances bind externally to DNA probably self-aggregating along the double helix. When the DNA concentration is large enough, the aggregate breaks up and the complex intercalates within the nucleobases. The complexes self-aggregate, without added DNA, in the presence of a large salt concentration.

DNA interaction of platinum(II) complexes with 1,10-phenanthroline and extended phenanthrolines

CUSUMANO, Matteo;DI PIETRO, Maria Letizia;GIANNETTO, Antonino
2006-01-01

Abstract

The interaction with DNA of the platinum(II) square planar complexes [Pt(N-N)(py)2]2+ (N-N ) = 1,10-phenanthroline (phen), dipyrido[3,2-d2’,3’-f]quinoxaline (dpq), dipyrido[3,2-a2’,3’-c]phenazine (dppz), benzodipyrido[b:3,2-h:2’3’ f]phenazine (bdppz)) has been investigated by means of absorption, circular and linear dichroism spectroscopy, DNA melting, and viscosity. In the presence of excess [DNA] all the complexes intercalate to the double helix. For those with the most extended phenanthrolines the binding mode depends on the [DNA]/[complex] ratio (q); at low q values the substances bind externally to DNA probably self-aggregating along the double helix. When the DNA concentration is large enough, the aggregate breaks up and the complex intercalates within the nucleobases. The complexes self-aggregate, without added DNA, in the presence of a large salt concentration.
2006
File in questo prodotto:
Non ci sono file associati a questo prodotto.
Pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11570/1715470
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 85
  • ???jsp.display-item.citation.isi??? 85
social impact