Cardiomyocytes can produce erythropoietin, as they can express HIF-1 in hypoxic conditions.1 In this regard, we found that the rat cardiomyoblast cell line H9c2 expresses erythropoietin mRNA, and a trend for hypoxia increased erythropoietin mRNA was observed in these cells (not shown). A contribution of infiltrating mononuclear cells and of endothelial cells, as suggested by the immunohistochemistry results, cannot be excluded.In conclusion, this is the first study showing that the ischaemic heart can produce erythropoietin. Owing to the cardioprotective effects of erythropoietin, our results suggest the possibility of a local mechanism of erythropoietin mediated protection in the ischaemic heart.
Increased erythropoietin production after myocardial infarction in mice
SFACTERIA, Alessandra;PIEDIMONTE, Giuseppe;
2006-01-01
Abstract
Cardiomyocytes can produce erythropoietin, as they can express HIF-1 in hypoxic conditions.1 In this regard, we found that the rat cardiomyoblast cell line H9c2 expresses erythropoietin mRNA, and a trend for hypoxia increased erythropoietin mRNA was observed in these cells (not shown). A contribution of infiltrating mononuclear cells and of endothelial cells, as suggested by the immunohistochemistry results, cannot be excluded.In conclusion, this is the first study showing that the ischaemic heart can produce erythropoietin. Owing to the cardioprotective effects of erythropoietin, our results suggest the possibility of a local mechanism of erythropoietin mediated protection in the ischaemic heart.Pubblicazioni consigliate
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