The dependence of the pseudo first order rate constant on the ionic strength for the alkaline hydrolysis of indomethacin has been obtained, for the first time, in a single kinetic experiment carried out by varying with time the salt concentration inside the reaction vessel. The kinetic profile obtained has been processed using as mathematical model the variable-parameter kinetic equation containing as dependence function the Bronsted–Bjerrum equation. Results are in good agreement with those obtained by the traditional method but the experimental time is reduced to about one tenth.
Variable-ionic strength kinetic experiments in drug stability studies
ALIBRANDI, Giuseppe;COPPOLINO, Salvatore;D'ALIBERTI, Santi;FICARRA, Paola;VILLARI, Antonino Gaet.
2003-01-01
Abstract
The dependence of the pseudo first order rate constant on the ionic strength for the alkaline hydrolysis of indomethacin has been obtained, for the first time, in a single kinetic experiment carried out by varying with time the salt concentration inside the reaction vessel. The kinetic profile obtained has been processed using as mathematical model the variable-parameter kinetic equation containing as dependence function the Bronsted–Bjerrum equation. Results are in good agreement with those obtained by the traditional method but the experimental time is reduced to about one tenth.File in questo prodotto:
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