Aim: We sought to evaluate the relationship between left ventricular systolic wall stress (LV-SWS) and coronary artery blood flow velocity in patients with LV hypertrophy (LVH). Methods and Results: The study population comprised 38 patients, aged 66.7 ± 12.7, who were divided into two groups based on the LV-SWS median value. Group A included 19 patients at "low-stress" (92.0 ± 18.0 mmHg/cm2) and group B other 19 patients at "high-stress" (134.2 ± 32.3 mmHg/cm2) (P < 0.002). Coronary blood flow velocities were measured both in the left anterior descending (LAD) and in the intramural (IM) arteries. There were no significant between-group differences in the main clinical and echocardiographic parameters. Diastolic velocity in the LAD was also comparable, while it was higher in the IM arterioles of patients from group B than from group A (peak velocity 110.9 ± 35.2 cm/s vs 92.0 ± 29.4 cm/s, P < 0.02; mean velocity 78.6 ± 28.8 vs. 56.0 ± 20.2 cm/s, P < 0.01, respectively). Overall, moderate, but significative, linear correlation was found between IM peak and mean diastolic velocity and LV-SWS (r = 0.41, P = 0.01, and r = 0.44, P = 0.007, respectively), whereas there was no correlation with wall thickening and LV mass. Conclusions: Main findings from the present study likely suggest that in patients with mild-to-moderate LVH, high blood flow velocity in the IM arterioles, but not in the LAD, may be related to an increase in LV-SWS, rather independent on the absolute LV mass.

Systolic wall stress may affect the intramural coronary blood flow velocity in myocardial hypertrophy, independently on the left ventricular mass

DE GREGORIO, Cesare;MICARI A;DI BELLA, Gianluca;CARERJ, Scipione;COGLITORE, Sebastiano
2005-01-01

Abstract

Aim: We sought to evaluate the relationship between left ventricular systolic wall stress (LV-SWS) and coronary artery blood flow velocity in patients with LV hypertrophy (LVH). Methods and Results: The study population comprised 38 patients, aged 66.7 ± 12.7, who were divided into two groups based on the LV-SWS median value. Group A included 19 patients at "low-stress" (92.0 ± 18.0 mmHg/cm2) and group B other 19 patients at "high-stress" (134.2 ± 32.3 mmHg/cm2) (P < 0.002). Coronary blood flow velocities were measured both in the left anterior descending (LAD) and in the intramural (IM) arteries. There were no significant between-group differences in the main clinical and echocardiographic parameters. Diastolic velocity in the LAD was also comparable, while it was higher in the IM arterioles of patients from group B than from group A (peak velocity 110.9 ± 35.2 cm/s vs 92.0 ± 29.4 cm/s, P < 0.02; mean velocity 78.6 ± 28.8 vs. 56.0 ± 20.2 cm/s, P < 0.01, respectively). Overall, moderate, but significative, linear correlation was found between IM peak and mean diastolic velocity and LV-SWS (r = 0.41, P = 0.01, and r = 0.44, P = 0.007, respectively), whereas there was no correlation with wall thickening and LV mass. Conclusions: Main findings from the present study likely suggest that in patients with mild-to-moderate LVH, high blood flow velocity in the IM arterioles, but not in the LAD, may be related to an increase in LV-SWS, rather independent on the absolute LV mass.
2005
File in questo prodotto:
Non ci sono file associati a questo prodotto.
Pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11570/1726403
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? 1
  • Scopus 6
  • ???jsp.display-item.citation.isi??? 5
social impact