We investigated synaptic plasticity in persons with Down' syndrome (DS) and control subjects used paired associative stimulation (PAS) protocol, a paradigm capable of producing long-term potentiation (LTP)-like changes in the sensorimotor system. After PAS, patients showed less LTP-like plasticity compared to control subjects. Abnormal motor cortex synaptic plasticity may play a role in the development of motor signs in DS.
Early impairment of synaptic plasticity in patients with Down's syndrome
BATTAGLIA, Fortunato
Primo
;QUARTARONE, Angelo;RIZZO, VINCENZO;TORTORELLA, Gaetano;GIRLANDA, PaoloUltimo
2008-01-01
Abstract
We investigated synaptic plasticity in persons with Down' syndrome (DS) and control subjects used paired associative stimulation (PAS) protocol, a paradigm capable of producing long-term potentiation (LTP)-like changes in the sensorimotor system. After PAS, patients showed less LTP-like plasticity compared to control subjects. Abnormal motor cortex synaptic plasticity may play a role in the development of motor signs in DS.File in questo prodotto:
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2008 Neurob of aging Battaglia Down.pdf
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