Abstract Exogenous PGE2 strongly inhibits the response of human lymphocyte cultures to SRBC. This effect is mediated through a T cell inhibition since non-T cells are not significantly affected. Indomethacin, which inhibits in this system lymphocyte endogenous PGE2 synthesis increases the in vitro immune response. The effect of indomethacin is overcame by exogenous PGE2. These data may be relevant for explaining the immunomodulatory role of PGE2 following antigen challenge.
PROSTAGLANDIN E2-INDUCED INHIBITION OF THE INVITRO IMMUNE- RESPONSE BY SRBC-STIMULATED HUMAN-LYMPHOCYTES
MISEFARI, Aldo;VALENTI, Andrea;CAVALLARO, Antonia;SOFO, Vincenza;SANTARPIA, Gerardo;SALMERI, Francesca Maria;TETI, Diana
1991-01-01
Abstract
Abstract Exogenous PGE2 strongly inhibits the response of human lymphocyte cultures to SRBC. This effect is mediated through a T cell inhibition since non-T cells are not significantly affected. Indomethacin, which inhibits in this system lymphocyte endogenous PGE2 synthesis increases the in vitro immune response. The effect of indomethacin is overcame by exogenous PGE2. These data may be relevant for explaining the immunomodulatory role of PGE2 following antigen challenge.File in questo prodotto:
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