The aim of our work was to investigate the ability of nonpeptidic vinyl and allyl phosphonates to inhibit falcipain-2 (FP-2), the main cysteine protease of P. falciparum. Some of the compounds synthesized, such as the one shown, moderately inhibit FP-2 activity.
Nonpeptidic Vinyl and Allyl Phosphonates as Falcipain-2 Inhibitors
ETTARI, Roberta;MICALE, Nicola;GRASSO, Silvana;ZAPPALA', Maria;
2008-01-01
Abstract
The aim of our work was to investigate the ability of nonpeptidic vinyl and allyl phosphonates to inhibit falcipain-2 (FP-2), the main cysteine protease of P. falciparum. Some of the compounds synthesized, such as the one shown, moderately inhibit FP-2 activity.File in questo prodotto:
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