A synthesis of some 1,2-(hetero)arylsubstituted ethanone and 1,3-(hetero)arylsubstituted3-hydroxypropenone derivatives, designed as potential HIV-1 integrase inhibitors, is reported. The microwave-assisted synthesis was applied in several reactions achieving reductions in reaction times and high yields. All compounds prepared were tested to explore their potential anti-HIV activity.
Synthesis of new potential HIV-1 integrase inhibitors
FERRO, Stefania;RAO, Angela;ZAPPALA', Maria;CHIMIRRI, Alba;BARRECA, Maria Letizia;MONFORTE, Pietro
2004-01-01
Abstract
A synthesis of some 1,2-(hetero)arylsubstituted ethanone and 1,3-(hetero)arylsubstituted3-hydroxypropenone derivatives, designed as potential HIV-1 integrase inhibitors, is reported. The microwave-assisted synthesis was applied in several reactions achieving reductions in reaction times and high yields. All compounds prepared were tested to explore their potential anti-HIV activity.File in questo prodotto:
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