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EnglishChlamydophila infection is known as an occupational hazard to veterinarians, farmers, poultry workers. Serum levels of the soluble Intercellular Adhesion Molecule-1 (sICAM-1), is associated with C. seropositivity. Since no data about ICAM-1 levels and C. psittaci infection are known, the aim of this work was to assess if chronic persistent C. psittaci infection constantly stimulates the expression of sICAM-1, independent of the characteristic symptoms of ornithosis. C. psittaci seropositivity and serum concentrations of sICAM-1 were investigated in 30 farmers and 20 age-matched healthy public employees as controls. Increased serum sICAM-1 levels were found in the group of farmers exposed to infectious risk compared to controls, and the serum concentrations of sICAM- 1 was signifi cantly correlated with a high IgG titre against C. psittaci. It is therefore possible to suggest a sICAM-1 measurement for use as a tool to verify the development of C. psittaci chronic infection in an occupational setting.
| Titolo: | Chlamydophila psittaci seropositivity and serum levels of soluble intercellular adhesion molecule-1 in farmers. |
| Autori: | |
| Data di pubblicazione: | 2008 |
| Rivista: | |
| Abstract: | Chlamydophila infection is known as an occupational hazard to veterinarians, farmers, poultry workers. Serum levels of the soluble Intercellular Adhesion Molecule-1 (sICAM-1), is associated with C. seropositivity. Since no data about ICAM-1 levels and C. psittaci infection are known, the aim of this work was to assess if chronic persistent C. psittaci infection constantly stimulates the expression of sICAM-1, independent of the characteristic symptoms of ornithosis. C. psittaci seropositivity and serum concentrations of sICAM-1 were investigated in 30 farmers and 20 age-matched healthy public employees as controls. Increased serum sICAM-1 levels were found in the group of farmers exposed to infectious risk compared to controls, and the serum concentrations of sICAM- 1 was signifi cantly correlated with a high IgG titre against C. psittaci. It is therefore possible to suggest a sICAM-1 measurement for use as a tool to verify the development of C. psittaci chronic infection in an occupational setting. |
| Handle: | http://hdl.handle.net/11570/1897860 |
| Appare nelle tipologie: | 14.a.1 Articolo su rivista |
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