Alzheimer’s disease is a growing global public health concern. Advanced research protocols to understand the pathogenesis of the molecular mechanisms of Alzheimer’s disease run parallel to dedicated research to determine the risk factors in this global scientific crusade. Detailed understanding of the underlying molecular mechanisms of this disease suggests that the amyloid beta peptide (Ab), hallmark of the disease, is subject to Ab oligomerization, a process that increases synaptotoxicity. Increased aggregation of Ab through the stabilization of intermediate toxic oligomers is thought to contribute to neurocognitive dysfunction.
Can a call for prudence be simply alarmist?
FODALE, Vincenzo
2009-01-01
Abstract
Alzheimer’s disease is a growing global public health concern. Advanced research protocols to understand the pathogenesis of the molecular mechanisms of Alzheimer’s disease run parallel to dedicated research to determine the risk factors in this global scientific crusade. Detailed understanding of the underlying molecular mechanisms of this disease suggests that the amyloid beta peptide (Ab), hallmark of the disease, is subject to Ab oligomerization, a process that increases synaptotoxicity. Increased aggregation of Ab through the stabilization of intermediate toxic oligomers is thought to contribute to neurocognitive dysfunction.File in questo prodotto:
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