A composite kinetic molecular device formed by a molecular titrator ([1.1.1]cryptand (A)) and a molecular pH meter (bromothymol blue (B)) was used as a substitute for the usual physical apparatus to perform an automatic spectrophotometric determination of the pKa of nimesulide (C). The confinement of the whole apparatus inside the spectrophotometric cuvette makes high-throughput pKa and stability determination in pharmaceutical analysis possible.

Molecular apparatus for Automatic Titrations

ALIBRANDI, Giuseppe;LO VECCHIO, CARMELO;VILLARI, Antonino Gaet.;VILLARI, IOLE
2010-01-01

Abstract

A composite kinetic molecular device formed by a molecular titrator ([1.1.1]cryptand (A)) and a molecular pH meter (bromothymol blue (B)) was used as a substitute for the usual physical apparatus to perform an automatic spectrophotometric determination of the pKa of nimesulide (C). The confinement of the whole apparatus inside the spectrophotometric cuvette makes high-throughput pKa and stability determination in pharmaceutical analysis possible.
2010
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11570/1901620
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