A longitudinal study of sleep disorders in early-stage chronic kidney disease

Few studies have addressed thè problem of sleep disturbances in patients with early-stage chronic kidney disease (CKD). A total of 220 patients newly diagnosed with CKD and 220 patients newly diagnosed with chronic hepatitis C were studied within 1 month from thè diagnosis. They were evaluated by using thè Charlson Comorbidity Index, thè Pittsburgh Sleep Quality Index, and thè Beck Depression Inventory. Patients with CKD were followed up for 4 years. Sleep disturbances affected 59.5% of patients with chronic hepatitis C and 84.6% of patients with CKD. Sleeping disorders that were severe and peculiar in early CKD improved significantly over time. Beck Depression Inventory disclosed significant depression, which was ameliorated over time. Charlson Comorbidity Index was Constant over time, Logistic regression analysis failed to detect significant correlations for putative factors emerging from studies in hemodialyzed patients, with thè exception of depression.