Lennox-Gastaut syndrome in adulthood: clinical and EEG features.

Ferlazzo, E; Nikanorova, M; Italiano, Domenico; Bureau, M; Dravet, C; Calarese, Tiziana; Viallat, D; Kölmel, M; Bramanti, Placido; De Santi, L; Genton, P.

doi:10.1016/j.eplepsyres.2010.01.012

PURPOSE: We performed a retrospective study to investigate seizure, EEG, social and cognitive outcome in adult LGS subjects. METHODS: We retrospectively evaluated 27 LGS patients aged 40-59 years. We assessed in particular the evolution of different seizure types and EEG findings, as well as cognitive and social outcome. RESULTS: During the early stages of the disease, all patients presented tonic seizures (TS) during wakefulness and sleep, 20/27 had atypical absences (AA), more rarely other seizure types. EEG showed slow background activity in 21/27 patients, diffuse slow spike-wave discharges (DSSW) during wakefulness in 22/27, and bursts of diffuse fast rhythms (DFR) in sleep in all patients. At last observation, 11 patients only had TS during wakefulness, but all still presented TS during sleep; AA persisted in 6 patients. EEG showed normal BA in 12/27 patients; only 7/27 still presented DSSW. On the contrary, sleep EEG showed the persistence of DFR in all. A moderate to severe cognitive impairment was observed in 26/27 patients. CONCLUSIONS: In adult LGS patients TS during sleep remain the major seizure type; moreover, a standard waking EEG may be normal. Thus, polysomnography represents the most important mean of investigation also in adult LGS patients.

Titolo:	Lennox-Gastaut syndrome in adulthood: clinical and EEG features.
Autori:	Ferlazzo E Nikanorova M ITALIANO, DOMENICO Bureau M Dravet C CALARESE, tiziana Viallat D Kölmel M BRAMANTI, Placido De Santi L Genton P. mostra contributor esterni nascondi contributor esterni
Data di pubblicazione:	2010
Rivista:	EPILEPSY RESEARCH
Abstract:	PURPOSE: We performed a retrospective study to investigate seizure, EEG, social and cognitive outcome in adult LGS subjects. METHODS: We retrospectively evaluated 27 LGS patients aged 40-59 years. We assessed in particular the evolution of different seizure types and EEG findings, as well as cognitive and social outcome. RESULTS: During the early stages of the disease, all patients presented tonic seizures (TS) during wakefulness and sleep, 20/27 had atypical absences (AA), more rarely other seizure types. EEG showed slow background activity in 21/27 patients, diffuse slow spike-wave discharges (DSSW) during wakefulness in 22/27, and bursts of diffuse fast rhythms (DFR) in sleep in all patients. At last observation, 11 patients only had TS during wakefulness, but all still presented TS during sleep; AA persisted in 6 patients. EEG showed normal BA in 12/27 patients; only 7/27 still presented DSSW. On the contrary, sleep EEG showed the persistence of DFR in all. A moderate to severe cognitive impairment was observed in 26/27 patients. CONCLUSIONS: In adult LGS patients TS during sleep remain the major seizure type; moreover, a standard waking EEG may be normal. Thus, polysomnography represents the most important mean of investigation also in adult LGS patients.
Handle:	http://hdl.handle.net/11570/1906388
Appare nelle tipologie:	14.a.1 Articolo su rivista

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