A procedure to asses the influence of earthquake-induced pore-water pressure on the behavior of natural clay slopes is presented in the paper. An experimental-based pore-water pressure generation model was adopted to detect the occurrence and to evaluate the magnitude of the excess pore-water pressure. Refereeing to the infinite slope scheme the response was evaluated in terms of earthquakeinduced permanent displacements taking into account the reduction of critical acceleration due to excess pore-water pressure. A parametric analysis shows that soil plasticity and peak ground acceleration are the parameters which mostly affect the response in terms of displacements.