The effects of chiral discrimination of ibuprofen (IBP) on the complexation process with methyl-beta-cyclodextrin (Me-beta-CD) were investigated in the solid phase by FTIR-ATR spectroscopy and numerical simulation. The inclusion mechanism was deduced from the temperature-dependent analysis of the vibrational spectra, in the C=O stretching region, of complexes formed by Me-beta-CD with the two enantiomeric and the racemic forms of IBP. The mechanism turned out to be enthalpy-driven, with IBP enantiomers giving rise to more stable inclusion complexes with respect to the racemate.
Effect of the chiral discrimination on the vibrational properties of (R)-, (S)- and (R, S)-ibuprofen/methyl-beta-cyclodextrin inclusion complexes
CRUPI, Vincenza;MAJOLINO, Domenico;VENUTI, Valentina;
2011-01-01
Abstract
The effects of chiral discrimination of ibuprofen (IBP) on the complexation process with methyl-beta-cyclodextrin (Me-beta-CD) were investigated in the solid phase by FTIR-ATR spectroscopy and numerical simulation. The inclusion mechanism was deduced from the temperature-dependent analysis of the vibrational spectra, in the C=O stretching region, of complexes formed by Me-beta-CD with the two enantiomeric and the racemic forms of IBP. The mechanism turned out to be enthalpy-driven, with IBP enantiomers giving rise to more stable inclusion complexes with respect to the racemate.File in questo prodotto:
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