There is evidence that isolated maternal hypothyroxinemia may have detrimental effects on both mother and foetus. Nonetheless, this condition is still far frombeing universally accepted as a separate thyroid disease, and a standard definition of this state of mild thyroid underfunction is still lacking.We will review the biochemical criteria used to define isolated maternal hypothyroxinemia, together with current methodological issues related to FT4 assays.We will also discuss its epidemiological impact in both iodinedeficient and-sufficient areas, and the effectiveness of iodine prophylaxis on maternal thyroid function and neuropsychomotor development in offspring

Doubts and Concerns about Maternal Hypothyroxinemia

MOLETI, MARIACARLA;TRIMARCHI, Francesco;VERMIGLIO, Francesco
2011

Abstract

There is evidence that isolated maternal hypothyroxinemia may have detrimental effects on both mother and foetus. Nonetheless, this condition is still far frombeing universally accepted as a separate thyroid disease, and a standard definition of this state of mild thyroid underfunction is still lacking.We will review the biochemical criteria used to define isolated maternal hypothyroxinemia, together with current methodological issues related to FT4 assays.We will also discuss its epidemiological impact in both iodinedeficient and-sufficient areas, and the effectiveness of iodine prophylaxis on maternal thyroid function and neuropsychomotor development in offspring
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11570/1911478
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