A two-level model is considered to describe the dynamics of a biological system undergoing cyclic transformations between two states separated by an energy quantum interval. This is typically met in enzyme-activated reactions involving the transition from ATP to ADP and vice versa, the two molecules which play a key role in the energetics of biosystems. The model has been worked out with reference to the ease of myosin ATPase, an enzyme involved in muscle contraction. General results can be obtained in analytical ways, when the dynamics of the system is investigated from sin energetic point of view. A system of two coupled differential equations follows whose stationary solutions recover several fundamental aspects of biomatter: i) a non-linear response to energy supply, ii) a switch from non-cooperative to cooperative laser-induced behaviour, iii) phase transitions appearance, iv) the increase of the order parameter, sustained by resonant irradiation. This final result may be the key to the interpretation of experimental results of enzyme reactivation by laser irradiation, usually not effective on undamaged enzymes, which can be related to the claimed healing effect of low-power laser.

The Electromagnetic-interaction In the Enzyme-activity Involving Atp

CAUSA, Federica;
1995

Abstract

A two-level model is considered to describe the dynamics of a biological system undergoing cyclic transformations between two states separated by an energy quantum interval. This is typically met in enzyme-activated reactions involving the transition from ATP to ADP and vice versa, the two molecules which play a key role in the energetics of biosystems. The model has been worked out with reference to the ease of myosin ATPase, an enzyme involved in muscle contraction. General results can be obtained in analytical ways, when the dynamics of the system is investigated from sin energetic point of view. A system of two coupled differential equations follows whose stationary solutions recover several fundamental aspects of biomatter: i) a non-linear response to energy supply, ii) a switch from non-cooperative to cooperative laser-induced behaviour, iii) phase transitions appearance, iv) the increase of the order parameter, sustained by resonant irradiation. This final result may be the key to the interpretation of experimental results of enzyme reactivation by laser irradiation, usually not effective on undamaged enzymes, which can be related to the claimed healing effect of low-power laser.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11570/1914418
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