A studywasundertakentodeterminethedistributionofspecifictypesofautonomic nerves andthepresenceofvarioustransmittersubstancesintheheartoftwoteleost species: themullet(Mugil cephalus) andtheNilecatfish(Synodontis nigriventris). Large nervetrunksinthesinusvenosuswereshowntocontaintyrosinehydroxylase immunoreactivity andindicatethelocationofadrenergicnervefibers,whichare also associatedwithacoronarycirculationtotheventricularmyocardiuminthe mullet heart.Fluorescenceimmunolabellingmethodsrevealedthattheatriumand the outerandinnercompactmuscleoftheventriclehavenervesinwhichsubstance P andgalanin(GA)arelocalized.Itseemslikelythatthecellbodies(perikarya)of the substancePandGA-immunopositiveaxonsarelocatedatsitesoutsidetheheart. The GA-immunopositivenervefibersmayrepresentapopulationofaxonsof intramural postganglionicnervecellbodies.Mostintracardiacnervecellbodiesare located inthesinusvenosusandinthesinoatrialjunctionandrevealimmunor- eactivity tosubstanceP,GA,neuronalnitricoxidesynthase(nNOS),vasoactive intestinal peptide(VIP)andpituitaryadenylatecyclase-activatingpeptide(PACAP). Furthermore, substancePimmunoreactivityispresentinthecardiaccells intermingled withthesubstanceP-immunopositivenervefibers.Anerveplexus consisting ofawell-developednetworkofnervefibersandnervecellbodiesmay possibly correspondtoacardiacpacemaker,butitsfunctioninfishcardiac regulation isunknownandremainstobeelucidated.
Postganglionic nerve cell bodies and neurotransmitter localization in the teleost heart.
ZACCONE, Giacomo;MAUCERI, Angela Rita;MAISANO, Maria;GIANNETTO, alessia;PARRINO, Vincenzo;FASULO, Salvatore
2010-01-01
Abstract
A studywasundertakentodeterminethedistributionofspecifictypesofautonomic nerves andthepresenceofvarioustransmittersubstancesintheheartoftwoteleost species: themullet(Mugil cephalus) andtheNilecatfish(Synodontis nigriventris). Large nervetrunksinthesinusvenosuswereshowntocontaintyrosinehydroxylase immunoreactivity andindicatethelocationofadrenergicnervefibers,whichare also associatedwithacoronarycirculationtotheventricularmyocardiuminthe mullet heart.Fluorescenceimmunolabellingmethodsrevealedthattheatriumand the outerandinnercompactmuscleoftheventriclehavenervesinwhichsubstance P andgalanin(GA)arelocalized.Itseemslikelythatthecellbodies(perikarya)of the substancePandGA-immunopositiveaxonsarelocatedatsitesoutsidetheheart. The GA-immunopositivenervefibersmayrepresentapopulationofaxonsof intramural postganglionicnervecellbodies.Mostintracardiacnervecellbodiesare located inthesinusvenosusandinthesinoatrialjunctionandrevealimmunor- eactivity tosubstanceP,GA,neuronalnitricoxidesynthase(nNOS),vasoactive intestinal peptide(VIP)andpituitaryadenylatecyclase-activatingpeptide(PACAP). Furthermore, substancePimmunoreactivityispresentinthecardiaccells intermingled withthesubstanceP-immunopositivenervefibers.Anerveplexus consisting ofawell-developednetworkofnervefibersandnervecellbodiesmay possibly correspondtoacardiacpacemaker,butitsfunctioninfishcardiac regulation isunknownandremainstobeelucidated.Pubblicazioni consigliate
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