Objectives: To evaluate carbonyl groups (CG) serum levels in B-chronic lymphocytic leukemia (B-CLL) patients. Design and methods: CG serum levels were assessed in 48 B-CLL patients and in 30 control subjects. Results: CG were increased in B-CLL patients. We found a positive correlation between CG with CD38 expression and a negative correlation with ZAP 70 expression. Conclusions: B-CLL patients displayed an unbalance of the oxidative stress. CG serum levels could be considered as a prognostic factor in B-CLL.
Carbonyl groups serum levels are associated with CD38 expression in patients with B chronic lymphocytic leucemia.
MUSOLINO, Caterina;ALLEGRA, Alessandro;ALONCI, Andrea;SAIJA, Antonina;CRISTANI, Mariateresa;SAITTA, SALVATORE;ALIBRANDI, Angela;GANGEMI, Sebastiano
2011-01-01
Abstract
Objectives: To evaluate carbonyl groups (CG) serum levels in B-chronic lymphocytic leukemia (B-CLL) patients. Design and methods: CG serum levels were assessed in 48 B-CLL patients and in 30 control subjects. Results: CG were increased in B-CLL patients. We found a positive correlation between CG with CD38 expression and a negative correlation with ZAP 70 expression. Conclusions: B-CLL patients displayed an unbalance of the oxidative stress. CG serum levels could be considered as a prognostic factor in B-CLL.File in questo prodotto:
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