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EnglishAim of our work was to study the histocompatibility antigen genes, HLA-A, B, C, DRB1 and DQB1, of Italian MM patients with dermatologic complications onset after lenalidomide treatment. Our study evidenced that patients having severe dermatologic complications (SJS and erythema multiforme) share HLA-DRB ∗ 1501 and HLA-DQB1 ∗ 0602, whereas patient with less severe dermatologic complications (urticaria) share HLADRB1 ∗ 1502 and HLA DQB1 ∗ 0601.
| Titolo: | Severe dermatologic adverse reactions after exposure to lenalidomide in multiple myeloma patients with a positive HLA-DRB1*1501 and HLA-DQB1*0602. |
| Autori: | |
| Data di pubblicazione: | 2012 |
| Rivista: | |
| Abstract: | Aim of our work was to study the histocompatibility antigen genes, HLA-A, B, C, DRB1 and DQB1, of Italian MM patients with dermatologic complications onset after lenalidomide treatment. Our study evidenced that patients having severe dermatologic complications (SJS and erythema multiforme) share HLA-DRB ∗ 1501 and HLA-DQB1 ∗ 0602, whereas patient with less severe dermatologic complications (urticaria) share HLADRB1 ∗ 1502 and HLA DQB1 ∗ 0601. |
| Handle: | http://hdl.handle.net/11570/1934771 |
| Appare nelle tipologie: | 14.a.1 Articolo su rivista |
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