The alterations in lactate metabolism in sepsis are mainly caused by modifications of the activity of the PDHK enzyme regulated by cytokines bat also by glucose uptake by GLUT1 and 4. LPS may therefore control lactate metabolism through cytokines production but may also reduce cardiac function by downregulating PPAR alpha activity and lipid metabolism leading to lipotoxicity.
Glucose and lipid metabolism in sepsis and endotoxemia.
SIRACUSANO, Luca;GIRASOLE, Viviana
2009-01-01
Abstract
The alterations in lactate metabolism in sepsis are mainly caused by modifications of the activity of the PDHK enzyme regulated by cytokines bat also by glucose uptake by GLUT1 and 4. LPS may therefore control lactate metabolism through cytokines production but may also reduce cardiac function by downregulating PPAR alpha activity and lipid metabolism leading to lipotoxicity.File in questo prodotto:
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