In this paper we want to evaluate if the variations of homocys- teine and folates levels in epileptic patients are in relation to the genetic mutations of the MTHFR enzyme. We have studied a group of 178 epileptic patients followed in the Neurological Clinic of Messina University. All the subjects have been classi¯ed in relationship to their different genotype: 677TT (homozygote); 677CT (heterozygote); C677T/1298AC (diplotipo or composed heterozygote). The statistical analysis has been performed by a non parametric approach, using permutation tests; we applied the NPC test in order to compare the three genotype in relationship to homocysteine and folates and the Stochastic Ordering procedure in order to assess the existence of a monotonous trend for homocysteine and folates levels in time.

A PERMUTATION APPROACH TO EVALUATEHYPERHOMOCYSTEINEMIA IN EPILEPTIC PATIENTS

ZIRILLI, Agata;ALIBRANDI, Angela
2009

Abstract

In this paper we want to evaluate if the variations of homocys- teine and folates levels in epileptic patients are in relation to the genetic mutations of the MTHFR enzyme. We have studied a group of 178 epileptic patients followed in the Neurological Clinic of Messina University. All the subjects have been classi¯ed in relationship to their different genotype: 677TT (homozygote); 677CT (heterozygote); C677T/1298AC (diplotipo or composed heterozygote). The statistical analysis has been performed by a non parametric approach, using permutation tests; we applied the NPC test in order to compare the three genotype in relationship to homocysteine and folates and the Stochastic Ordering procedure in order to assess the existence of a monotonous trend for homocysteine and folates levels in time.
File in questo prodotto:
Non ci sono file associati a questo prodotto.
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11570/1950216
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact