In this paper we want to evaluate if the variations of homocys- teine and folates levels in epileptic patients are in relation to the genetic mutations of the MTHFR enzyme. We have studied a group of 178 epileptic patients followed in the Neurological Clinic of Messina University. All the subjects have been classi¯ed in relationship to their different genotype: 677TT (homozygote); 677CT (heterozygote); C677T/1298AC (diplotipo or composed heterozygote). The statistical analysis has been performed by a non parametric approach, using permutation tests; we applied the NPC test in order to compare the three genotype in relationship to homocysteine and folates and the Stochastic Ordering procedure in order to assess the existence of a monotonous trend for homocysteine and folates levels in time.
A PERMUTATION APPROACH TO EVALUATEHYPERHOMOCYSTEINEMIA IN EPILEPTIC PATIENTS
ZIRILLI, Agata;ALIBRANDI, Angela
2009-01-01
Abstract
In this paper we want to evaluate if the variations of homocys- teine and folates levels in epileptic patients are in relation to the genetic mutations of the MTHFR enzyme. We have studied a group of 178 epileptic patients followed in the Neurological Clinic of Messina University. All the subjects have been classi¯ed in relationship to their different genotype: 677TT (homozygote); 677CT (heterozygote); C677T/1298AC (diplotipo or composed heterozygote). The statistical analysis has been performed by a non parametric approach, using permutation tests; we applied the NPC test in order to compare the three genotype in relationship to homocysteine and folates and the Stochastic Ordering procedure in order to assess the existence of a monotonous trend for homocysteine and folates levels in time.Pubblicazioni consigliate
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