Objectives: To clarify whether interleukin (IL)-23 is involved in peripheral arterial disease (PAD). Design and methods: We evaluated IL-23 serum levels, in 29 patients suffering from lower extremity PAD and in 30 healthy subjects. Results: IL-23 serum levels were higher during the three times (T0, T1 and T2) compared to the control group, although only statistically significant for T0 and T2: T0 (15.83±22.08 vs. 8.08±8.62 pgml, p=0.026), T1 (16.10±23.71 vs. 8.08±8.62 pg/ml, p=0.101), T2 (15.06±16.72 vs. 8.08±8.62 pg/ml, p=0.005). Conclusion: For the first time, our data gives us reason to believe there is an involvement of IL-23 in PAD.
Interleukin-23 serum levels in patients affected by peripheral arterial disease.
DAVID, Antonio;SAITTA, SALVATORE;DE CARIDI, GIOVANNI;BENEDETTO, FILIPPO;MASSARA, MAFALDA;VENUTI, Francesco Saverio;SPINELLI, Francesco;GANGEMI, Sebastiano
2012-01-01
Abstract
Objectives: To clarify whether interleukin (IL)-23 is involved in peripheral arterial disease (PAD). Design and methods: We evaluated IL-23 serum levels, in 29 patients suffering from lower extremity PAD and in 30 healthy subjects. Results: IL-23 serum levels were higher during the three times (T0, T1 and T2) compared to the control group, although only statistically significant for T0 and T2: T0 (15.83±22.08 vs. 8.08±8.62 pgml, p=0.026), T1 (16.10±23.71 vs. 8.08±8.62 pg/ml, p=0.101), T2 (15.06±16.72 vs. 8.08±8.62 pg/ml, p=0.005). Conclusion: For the first time, our data gives us reason to believe there is an involvement of IL-23 in PAD.Pubblicazioni consigliate
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