Hereinwereport a study on the enantioselective organocatalyzed cross-aldol reaction of 1-benzothiophene and thiophenecarbaldehydes with different ketones. The reactions were conducted at 0 C or room temperature to afford the corresponding adducts in high yields and good to excellent ee using different organocatalysts. Interestingly, using (S)-pyrrolidine tetrazole and acetoxyacetone an inversion of the aldol regiochemistry was observed

Enantioselective organocatalyzed functionalization of benzothiophene and thiophenecarbaldehyde derivatives

BRUNO, Giuseppe;NICOLO', Francesco
2012-01-01

Abstract

Hereinwereport a study on the enantioselective organocatalyzed cross-aldol reaction of 1-benzothiophene and thiophenecarbaldehydes with different ketones. The reactions were conducted at 0 C or room temperature to afford the corresponding adducts in high yields and good to excellent ee using different organocatalysts. Interestingly, using (S)-pyrrolidine tetrazole and acetoxyacetone an inversion of the aldol regiochemistry was observed
2012
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11570/1974459
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