Head and neck cancer is a definition used to describe squamous cell carcinomas that can develop in the throat, larynx, nose, sinuses, and mouth. Etiopathogenesis is due to tobacco and alcohol consumption and to infection from human papillomavirus (HPV) type 16/18. Tumors often develop within preneoplastic fields of genetically altered cells. Most head and neck cancers result from multistep accumulation of genetic alterations resulting in clonal outgrowth of transformed cells. These DNA changes are caused by a variety of mechanisms like endogenous mutations and exogenous mutations. Dysregulated molecular pathway includes alterations of critical inhibitor of cyclin CDK complexes, inactivating mutations of p53 gene, activation of oncogenes and growth factors. This article attempts to review the role of p53 and MDM2 genetic aberrations and pathways, in head and neck cancer.
The role of p53 and MDM2 in head and neck cancer
DENARO, NERINA;ADAMO, Vincenzo;
2011-01-01
Abstract
Head and neck cancer is a definition used to describe squamous cell carcinomas that can develop in the throat, larynx, nose, sinuses, and mouth. Etiopathogenesis is due to tobacco and alcohol consumption and to infection from human papillomavirus (HPV) type 16/18. Tumors often develop within preneoplastic fields of genetically altered cells. Most head and neck cancers result from multistep accumulation of genetic alterations resulting in clonal outgrowth of transformed cells. These DNA changes are caused by a variety of mechanisms like endogenous mutations and exogenous mutations. Dysregulated molecular pathway includes alterations of critical inhibitor of cyclin CDK complexes, inactivating mutations of p53 gene, activation of oncogenes and growth factors. This article attempts to review the role of p53 and MDM2 genetic aberrations and pathways, in head and neck cancer.Pubblicazioni consigliate
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