The present research reports a comparative study between conventional and split-flow comprehensive two-dimensional gas chromatography-mass spectrometry (GC×GC-MS). Conventional GC×GC-MS experiments were performed by using a single GC oven, and with a widely-employed apolar (30 m × 0.25 mm ID)-polar (1 m × 0.10 mm ID) column combination. Split-flow GC×GC-MS applications were carried out by using a single GC oven, the same first and second analytical columns, and by diverting part of the primarycapillary flow to waste via a waste line. The latter was located at the conjunction point between the two columns. Such a configuration enables the generation of ideal gas linear velocities in both analytical dimensions. The measurement of fundamental gas chromatography parameters (efficiency, resolution), in both dimensions and under different experimental conditions, enabled the attainment of detailed information related to GC×GC-MS method optimization.

A measurement of fundamental chromatography parameters In conventional and split-flow comprehensive two timensional gas chromatography-mass spectrometry: A comparative study

ZOCCALI, MARIOSIMONE;TRANCHIDA, Peter Quinto;DUGO, Paola;MONDELLO, Luigi
2012

Abstract

The present research reports a comparative study between conventional and split-flow comprehensive two-dimensional gas chromatography-mass spectrometry (GC×GC-MS). Conventional GC×GC-MS experiments were performed by using a single GC oven, and with a widely-employed apolar (30 m × 0.25 mm ID)-polar (1 m × 0.10 mm ID) column combination. Split-flow GC×GC-MS applications were carried out by using a single GC oven, the same first and second analytical columns, and by diverting part of the primarycapillary flow to waste via a waste line. The latter was located at the conjunction point between the two columns. Such a configuration enables the generation of ideal gas linear velocities in both analytical dimensions. The measurement of fundamental gas chromatography parameters (efficiency, resolution), in both dimensions and under different experimental conditions, enabled the attainment of detailed information related to GC×GC-MS method optimization.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11570/2036744
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