Hearing loss is not usually included in the clinical manifestations of congenital hypothyroidism. We found bilateral sensorineural non-retrocochlear hearing loss in 5 (24%) of 21 patients with congenital hypothyroidism aged 0.3 to 18.1 years. Hypothyroidism was diagnosed by another means than neonatal screening in most cases. Three of the five hearing-deficient patients also had disorders of speech. All patients were euthyroid at the time of this study. Average age at initiation of hormone replacement therapy was not significantly different in the five hearing-deficient patients and the sixteen normal-hearing patients. Hearing loss was not more prevalent in thyroid agenesis than in the other causes of hypothyroidism. None of the five hearing-deficient patients had started hormone replacement before the age of four months. In contrast, hypothyroid patients treated from the first month of life had normal hearing. In the five hearing-deficient patients mean IQ was subnormal and significantly lower than in the normal hearing group. Hearing loss was more prevalent in patients with an IQ < 85 than in those with IQ > 85 (5/12 versus 0/9). Thus, all the non-mentally deficient patients in our series had normal hearing, whereas all the patients with sensorineural hearing loss had mental subnormality. Our results confirm that sensorineural hearing loss is a fairly common manifestation of congenital hypothyroidism.
Sensorineural hearing loss with congenital hypothyroidism[HYPOACOUSIE DE TYPE PERCEPTIF ET HYPOTHYROIDIE CONGENITALE]
DE LUCA, Filippo;
1986-01-01
Abstract
Hearing loss is not usually included in the clinical manifestations of congenital hypothyroidism. We found bilateral sensorineural non-retrocochlear hearing loss in 5 (24%) of 21 patients with congenital hypothyroidism aged 0.3 to 18.1 years. Hypothyroidism was diagnosed by another means than neonatal screening in most cases. Three of the five hearing-deficient patients also had disorders of speech. All patients were euthyroid at the time of this study. Average age at initiation of hormone replacement therapy was not significantly different in the five hearing-deficient patients and the sixteen normal-hearing patients. Hearing loss was not more prevalent in thyroid agenesis than in the other causes of hypothyroidism. None of the five hearing-deficient patients had started hormone replacement before the age of four months. In contrast, hypothyroid patients treated from the first month of life had normal hearing. In the five hearing-deficient patients mean IQ was subnormal and significantly lower than in the normal hearing group. Hearing loss was more prevalent in patients with an IQ < 85 than in those with IQ > 85 (5/12 versus 0/9). Thus, all the non-mentally deficient patients in our series had normal hearing, whereas all the patients with sensorineural hearing loss had mental subnormality. Our results confirm that sensorineural hearing loss is a fairly common manifestation of congenital hypothyroidism.Pubblicazioni consigliate
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