We report a case of prolonged cardiac arrest with complete recovery following accidental intravenous (i.v.) self-administration of cisatracurium.The patient had self-administered cisatracurium. Laudanosine, a major metabolic degradation product of cisatracurium, crosses the blood–brain barrier and accumulates in cerebrospinal fluid [3]. Laudanosine, at concentrations comparable to those measured under clinical conditions in cerebrospinal fluid is able to activate alpha4beta2-nicotinic acetylcholine receptors. These receptors are present throughout the nervous system and are involved in chemical signalling. Several studies have suggested that alpha4beta2- nicotinic acetylcholine receptor activation elicits a neuroprotective effect, in vivo and in vitro. Therefore, it has been hypothesized that laudanosine, at clinical concentrations reported, could exhibit potential neuroprotective effects.

Complete recovery from prolonged cardiac arrest following self-administration of cisatracurium.

V. Fodale;C. Praticò;T. Lucanto;A. T. Mazzeo;L. B. Santamaria
2005

Abstract

We report a case of prolonged cardiac arrest with complete recovery following accidental intravenous (i.v.) self-administration of cisatracurium.The patient had self-administered cisatracurium. Laudanosine, a major metabolic degradation product of cisatracurium, crosses the blood–brain barrier and accumulates in cerebrospinal fluid [3]. Laudanosine, at concentrations comparable to those measured under clinical conditions in cerebrospinal fluid is able to activate alpha4beta2-nicotinic acetylcholine receptors. These receptors are present throughout the nervous system and are involved in chemical signalling. Several studies have suggested that alpha4beta2- nicotinic acetylcholine receptor activation elicits a neuroprotective effect, in vivo and in vitro. Therefore, it has been hypothesized that laudanosine, at clinical concentrations reported, could exhibit potential neuroprotective effects.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11570/2367085
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