The aim of this study was to assess the influence of different water quality of Faro Lake and Tyrrhenian Sea on the haematological and serum proteins profiles of Mugil cephalus. In both sampling sites water physical-chemical-parameters of the water colum were measured. Our results showed statistical difference in pH, salinity and dissolved oxygen between the two sites. White blood cells, total proteins, prealbumin, albumin and α-globulins showed a statistical significance in mullet dwell in two different habitat (Faro lake and Tyrrhenian Sea). The variations in haematological parameters and serum protein profile are a good indicators to detect intra and inter-specific variations in relation to different aquatic habitats. These results represent important haematological indices useful for monitoring the effect of environmental changes and physiological adaptive capacities of mullet.
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