This study investigated the role of cadmium, a widespread heavy metal in the aquatic environment, on cell volume regulation of digestive cells isolated from the digestive gland of Mytilus galloprovincialis. These cells when exposed to a rapid change (from 1100 to 800mOsm/kg) of the bathing solution osmolality swelled but thereafter underwent a Regulatory Volume Decrease (RVD), tending to recover the original size. This homeostatic response is altered by cadmium, as suggested by experiments performed both on isolated cells pre-incubated with cadmium (10-5M) and on cells isolated from animals exposed to sub-lethal concentrations of the metal (40μg/l for 21days). It is suggested that cytoskeleton and Na+/K+ATPase are the possible targets of cadmium which impairment is responsible of the altered homeostatic response
Effect of CdCl2 on Regulatory Volume Decrease (RVD) in Mytilus galloprovincialis digestive cells.
TRISCHITTA, Francesca Ross;FAGGIO, Caterina
2013-01-01
Abstract
This study investigated the role of cadmium, a widespread heavy metal in the aquatic environment, on cell volume regulation of digestive cells isolated from the digestive gland of Mytilus galloprovincialis. These cells when exposed to a rapid change (from 1100 to 800mOsm/kg) of the bathing solution osmolality swelled but thereafter underwent a Regulatory Volume Decrease (RVD), tending to recover the original size. This homeostatic response is altered by cadmium, as suggested by experiments performed both on isolated cells pre-incubated with cadmium (10-5M) and on cells isolated from animals exposed to sub-lethal concentrations of the metal (40μg/l for 21days). It is suggested that cytoskeleton and Na+/K+ATPase are the possible targets of cadmium which impairment is responsible of the altered homeostatic responsePubblicazioni consigliate
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