Age, Glomerular filtration rate, Ejection Fraction and the AGEF score predict Contrast-Induced Nephropathy in patients with acute myocardial infarction undergoing primary percutaneous coronary intervention

Background: In patients undergoing primary percutaneous coronary interventions (PCI) for ST-segment elevation myocardial infarction (STEMI), the occurrence of Contrast-Induced Nephropathy (CIN) has a pronounced impact both on morbidity and mortality. We investigated the variables associated with CIN development in 481 consecutive patients with STEMI undergoing primary PCI and evaluated the predictive value of a 3-variable clinical risk score (the AGEF score) based on age, left ventricular ejection fraction (EF), and estimated glomerular filtration rate (eGFR). Methods: CIN was defined as an absolute increase in serum creatinine 0.5 mg/dL or an increase 25% from baseline within 72 hr. AGEF score was cal- culated by adding 1 point to the Age/EF(%) ratio if the eGFR was <60 mL/min per 1.73 m2. Results: Overall, the incidence of CIN was 5.2%. In-hospital mortality was higher in patients with CIN than in those without (16% Vs 1.3%, P50.001). At multivariate analysis age (OR 1.06, P50.042), eGFR (OR 0.95, P50.001), EF (OR 0.94, P50.007) and post-procedural TIMI flow grade (OR 0.43, P 5 0.045) were in- dependent predictors of CIN. AGEF score was an accurate (OR 5.19, P<0.001, AUC 0.88) and calibrated (Hosmer-Lemeshow v2 5 10.25, P 5 0.25) predictor of CIN. Conclusions: Advanced age, depressed EF, and reduced eGFR are independ- ent predictors of CIN development after primary PCI for STEMI. The preprocedural individual patient risk can be clinically assessed with the calculation of the AGEF score, which is based on such readily available parameters.