Background: The aim of this study was to evaluate long-term efficacy, safety, stability, and predictability of photorefractive keratectomy (PRK) as treatment of astigmatism. Material/Methods: Ninety-four eyes of 52 patients, treated with PRK for compound myopic astigmatism, compound hyperopic astigmatism, and mixed astigmatism were studied during a 36-month period. Main outcome measures were uncorrected and best-corrected visual acuity (UCVA, BCVA), refraction, and corneal transparency. Astigmatism correction was analyzed by a power vector method. Results: In myopic astigmatism group (42 eyes), postoperative UCVA was 20/40 or better in 100% of eyes, 20/25 or better in 38 eyes out of 42 (90.5%), and 20/20 or better in 25/42 eyes (59.5%). No eye lost lines of the BCVA, 40/42 (95.2%) eyes had refraction within ±1D and 37/42 (88.1%) within ±0.50 D. In the hyperopic astigmatism group (28 eyes), the UCVA was 20/40 or better in 100% of eyes, 20/25 or better in 26/28 eyes (92.8%), and 20/20 or better in 24/28 eyes (85.7%); 1/28 eyes (3.6%) lost 1 line of the BCVA, 23/28 eyes (82.1%) were with¬in ±1D, and 21/28 (75%) were within ±0.50D. In the mixed astigmatism group (24 eyes), the UCVA was 20/40 or better in 100% of eyes, 20/25 or better in 22/24 eyes (91.7%) and 20/20 in 15/24 (62.5%) eyes. No eye lost lines of BCVA, 23/24 eyes (95.8%) were within 1.0 D, and 20/24 eyes (83.3%) were within 0.50 D of defocus refraction. Power vector analysis showed a significant reduction of blurring strength in all examined groups. Conclusions: PRK is a safe and effective procedure for correction of all types of astigmatism, with good stability and efficacy at 3-year follow-up.
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