In continuation of our research efforts toward the identification and optimization for novel inhibitors of interaction between human immunodeficiency virus type 1 integrase and cellular cofactor LEDGF/p75, we designed and synthesized a new series of 4-benzylindole derivatives. Most of the title compounds proved to be able to block this protein-protein interaction (PPI), with a percentage ranging from 30% to 90% at 100 μM. The most promising derivative was compound 10b showing IC50 value of 6.41 μM. The main structure-activity relationships (SAR) are discussed and rationalized by docking studies.
Synthesis and biological evaluation of novel antiviral agents as protein–protein interaction inhibitors
FERRO, Stefania;DE LUCA, Laura;GITTO, Rosaria;CHIMIRRI, Alba
2014-01-01
Abstract
In continuation of our research efforts toward the identification and optimization for novel inhibitors of interaction between human immunodeficiency virus type 1 integrase and cellular cofactor LEDGF/p75, we designed and synthesized a new series of 4-benzylindole derivatives. Most of the title compounds proved to be able to block this protein-protein interaction (PPI), with a percentage ranging from 30% to 90% at 100 μM. The most promising derivative was compound 10b showing IC50 value of 6.41 μM. The main structure-activity relationships (SAR) are discussed and rationalized by docking studies.File in questo prodotto:
Non ci sono file associati a questo prodotto.
Pubblicazioni consigliate
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.