The design of b-cyclodextrin/multiwalled carbon nanotubes hybrid (b-CD-MWCNT) as nanoplatform for the entrapment and delivery of guanine based drugs is described here. The functionalized carbon nanomaterials have been characterized by XPS spectroscopy, electron microscopy (FEG-SEM and TEM), AFM, TGA, and FT-IR to achieve insights on structure, morphology and chemical composition. The drug binding abilities of nanocarrier towards the guanine (G) and Acyclovir (Acy) were proved by UV–vis and DSC experiments. Host–guest equilibrium association constants and drug loading have been evaluatedfor G/b-CD-MWCNT and Acy/b-CD-MWCNT complexes. The release studies showed a sustained deliveryof Acy without initial burst effect confirming a strong interaction of drug with the nanoplatform sites. The preliminary antiviral data indicated that the Acyclovir loaded into the b-CD-MWCNT platform interfereswith HSV-1 replication and the antireplicative effect was higher than the free drug.

b-Cyclodextrin-grafted on multiwalled carbon nanotubes as versatilenanoplatform for entrapment of guanine-based drugs

IANNAZZO, Daniela;SCALA, ANGELA;PISTONE, Alessandro;GALVAGNO, Signorino;COLAO, IVANA;SCIORTINO, Maria Teresa;PIPERNO, Anna;GRASSI, Giovanni
2014

Abstract

The design of b-cyclodextrin/multiwalled carbon nanotubes hybrid (b-CD-MWCNT) as nanoplatform for the entrapment and delivery of guanine based drugs is described here. The functionalized carbon nanomaterials have been characterized by XPS spectroscopy, electron microscopy (FEG-SEM and TEM), AFM, TGA, and FT-IR to achieve insights on structure, morphology and chemical composition. The drug binding abilities of nanocarrier towards the guanine (G) and Acyclovir (Acy) were proved by UV–vis and DSC experiments. Host–guest equilibrium association constants and drug loading have been evaluatedfor G/b-CD-MWCNT and Acy/b-CD-MWCNT complexes. The release studies showed a sustained deliveryof Acy without initial burst effect confirming a strong interaction of drug with the nanoplatform sites. The preliminary antiviral data indicated that the Acyclovir loaded into the b-CD-MWCNT platform interfereswith HSV-1 replication and the antireplicative effect was higher than the free drug.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11570/3010368
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