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EnglishTertiary lymphoid structures (TLSs) are a common finding in non-small cell lung cancer (NSCLC) and are predictors of favourable clinical outcome. Here we show that NCR+ innate lymphoid cell (ILC)-3 are present in the lymphoid infiltrate of human NSCLC and are mainly localized at the edge of tumour-associated TLSs. This intra-tumoral lymphocyte subset is endowed with lymphoid tissue-inducing properties and, on activation, produces IL-22, TNF-α, IL-8 and IL-2, and activates endothelial cells. Tumour NCR+ ILC3 may interact with both lung tumour cells and tumour-associated fibroblasts, resulting in the release of cytokines primarily on engagement of the NKp44-activating receptor. In patients, NCR+ ILC3 are present in significantly higher amounts in stage I/II NSCLC than in more advanced tumour stages and their presence correlate with the density of intratumoral TLSs. Our results indicate that NCR+ ILC3 accumulate in human NSCLC tissue and might contribute to the formation of protective tumour-associated TLSs.
| Titolo: | NCR(+)ILC3 concentrate in human lung cancer and associate with intratumoral lymphoid structures. |
| Autori: | CARREGA, Paolo (Primo) FERLAZZO, Guido (Ultimo) (Corresponding) |
| Data di pubblicazione: | 2015 |
| Rivista: | |
| Abstract: | Tertiary lymphoid structures (TLSs) are a common finding in non-small cell lung cancer (NSCLC) and are predictors of favourable clinical outcome. Here we show that NCR+ innate lymphoid cell (ILC)-3 are present in the lymphoid infiltrate of human NSCLC and are mainly localized at the edge of tumour-associated TLSs. This intra-tumoral lymphocyte subset is endowed with lymphoid tissue-inducing properties and, on activation, produces IL-22, TNF-α, IL-8 and IL-2, and activates endothelial cells. Tumour NCR+ ILC3 may interact with both lung tumour cells and tumour-associated fibroblasts, resulting in the release of cytokines primarily on engagement of the NKp44-activating receptor. In patients, NCR+ ILC3 are present in significantly higher amounts in stage I/II NSCLC than in more advanced tumour stages and their presence correlate with the density of intratumoral TLSs. Our results indicate that NCR+ ILC3 accumulate in human NSCLC tissue and might contribute to the formation of protective tumour-associated TLSs. |
| Handle: | http://hdl.handle.net/11570/3064610 |
| Appare nelle tipologie: | 14.a.1 Articolo su rivista |
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|---|---|---|---|---|
| Carrega et al., 2015.pdf | Versione Editoriale (PDF) |  | Open Access Visualizza/Apri |
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