OBJECTIVES: To investigate the distribution of MTHFR C677T and A1298C as well as PON1 Q192R gene polymorphisms, known to be involved in hyperhomocysteinemia-related cardiovascular risk, in elite athletes. DESIGN AND METHODS: Genetic background at MTHFR and PON1 loci and plasma levels of homocysteine, folate, vitamin B12 and advanced oxidation protein product (AOPP) levels were assessed in thirty-seven 400m male hurdlers and thirty-four sedentary subjects. RESULTS: Homocysteine plasma levels and AOPPs were significantly higher in hurdlers bearing the TT677/AA1298 diplotype than in both hurdlers and sedentary subjects with other diplotypes. A positive dependence between either homocysteine or AOPP plasma levels and MTHFR, but not PON1 genotype, was observed in hurdlers. CONCLUSIONS: Elite hurdlers, having an unfavorable MTHFR genotype are exposed to increased cardiovascular risk, dependent on alterations of homocysteine and AOPP plasma levels.

Influence of MTHFR polymorphisms on cardiovascular risk markers in elite athletes

CURRO', MONICA
Primo
Investigation
;
DI MAURO, Debora
Secondo
Investigation
;
BRUSCHETTA, Daniele
Data Curation
;
TRIMARCHI, Fabio
Resources
;
IENTILE, Riccardo
Penultimo
Conceptualization
;
CACCAMO, Daniela
Ultimo
Writing – Review & Editing
2016-01-01

Abstract

OBJECTIVES: To investigate the distribution of MTHFR C677T and A1298C as well as PON1 Q192R gene polymorphisms, known to be involved in hyperhomocysteinemia-related cardiovascular risk, in elite athletes. DESIGN AND METHODS: Genetic background at MTHFR and PON1 loci and plasma levels of homocysteine, folate, vitamin B12 and advanced oxidation protein product (AOPP) levels were assessed in thirty-seven 400m male hurdlers and thirty-four sedentary subjects. RESULTS: Homocysteine plasma levels and AOPPs were significantly higher in hurdlers bearing the TT677/AA1298 diplotype than in both hurdlers and sedentary subjects with other diplotypes. A positive dependence between either homocysteine or AOPP plasma levels and MTHFR, but not PON1 genotype, was observed in hurdlers. CONCLUSIONS: Elite hurdlers, having an unfavorable MTHFR genotype are exposed to increased cardiovascular risk, dependent on alterations of homocysteine and AOPP plasma levels.
2016
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11570/3069720
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