PURPOSE. To investigate corneal confocal microscopic changes in nonneoplastic and neoplastic monoclonal gammopathies. METHODS. Three groups of subjects were considered: group 1, twenty normal subjects; group 2, fifteen patients with monoclonal gammopathy of undetermined significance (MGUS); group 3, eight patients with smoldering multiple myeloma and eight patients with untreated multiple myeloma. After hematologic diagnosis, patients underwent ophthalmologic exam and in vivo confocal microscopic study. The statistical analysis was performed using ANOVA and Student-Newman-Keuls tests and receiver operating characteristic (ROC) curve analysis. RESULTS. Epithelial cells of gammopathic patients showed significantly higher reflectivity than controls, demonstrated by optical density (P < 0.001). Subbasal nerve density, branching, and beading were significantly altered in gammopathic patients (P . 0.01, P . 0.02, P . 0.02, respectively). The number of keratocytes was significantly reduced in neoplastic patients (P <0.001 versus both normal and MGUS) in the anterior, medium, and posterior stroma. The ROC curve analysis showed good sensitivity and specificity for this parameter. Group 2 and 3 keratocytes showed higher nuclear and cytoplasmatic reflectivity in the medium and posterior stroma. Endothelial cells were not affected. CONCLUSIONS. Patients with neoplastic gammopathies showed peculiar alterations of the keratocyte number, which appeared significantly reduced. A follow-up with corneal confocal microscopy of patients with MGUS is suggested as a useful tool to identify peripheral tissue alterations linked to possible neoplastic disease development.

Corneal Structural Changes in Nonneoplastic and Neoplastic Monoclonal Gammopathies

ARAGONA, Pasquale
Primo
;
ALLEGRA, Alessandro;POSTORINO, ELISA IMELDE;RANIA, Laura;INNAO, Vanessa;IENI, ANTONIO;PISANI, Antonina Maria;MUSOLINO, Caterina;PUZZOLO, Domenico;MICALI, Antonio Girolamo
Ultimo
2016-01-01

Abstract

PURPOSE. To investigate corneal confocal microscopic changes in nonneoplastic and neoplastic monoclonal gammopathies. METHODS. Three groups of subjects were considered: group 1, twenty normal subjects; group 2, fifteen patients with monoclonal gammopathy of undetermined significance (MGUS); group 3, eight patients with smoldering multiple myeloma and eight patients with untreated multiple myeloma. After hematologic diagnosis, patients underwent ophthalmologic exam and in vivo confocal microscopic study. The statistical analysis was performed using ANOVA and Student-Newman-Keuls tests and receiver operating characteristic (ROC) curve analysis. RESULTS. Epithelial cells of gammopathic patients showed significantly higher reflectivity than controls, demonstrated by optical density (P < 0.001). Subbasal nerve density, branching, and beading were significantly altered in gammopathic patients (P . 0.01, P . 0.02, P . 0.02, respectively). The number of keratocytes was significantly reduced in neoplastic patients (P <0.001 versus both normal and MGUS) in the anterior, medium, and posterior stroma. The ROC curve analysis showed good sensitivity and specificity for this parameter. Group 2 and 3 keratocytes showed higher nuclear and cytoplasmatic reflectivity in the medium and posterior stroma. Endothelial cells were not affected. CONCLUSIONS. Patients with neoplastic gammopathies showed peculiar alterations of the keratocyte number, which appeared significantly reduced. A follow-up with corneal confocal microscopy of patients with MGUS is suggested as a useful tool to identify peripheral tissue alterations linked to possible neoplastic disease development.
2016
File in questo prodotto:
File Dimensione Formato  
IOVS Mieloma paper 2016.pdf

accesso aperto

Descrizione: Versione e-pub
Tipologia: Versione Editoriale (PDF)
Licenza: Creative commons
Dimensione 829.11 kB
Formato Adobe PDF
829.11 kB Adobe PDF Visualizza/Apri
Corneal_Structural_2016.pdf

accesso aperto

Descrizione: Articolo principale a stampa
Tipologia: Versione Editoriale (PDF)
Licenza: Creative commons
Dimensione 838.26 kB
Formato Adobe PDF
838.26 kB Adobe PDF Visualizza/Apri
Pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11570/3089372
Citazioni
  • ???jsp.display-item.citation.pmc??? 8
  • Scopus 19
  • ???jsp.display-item.citation.isi??? 15
social impact