A powerful, novel approach to meroterpenes conicol, epiconicol and didehydroconicol has been achieved via a key step DielseAlder reaction of (E)-3-methyl-1-(2’,5’ -dimethoxyphenyl)buta-1,3-diene as diene with methyl vinyl ketone, methyl acrylate or methyl propiolate as dienophiles. Activation by high pressure (9 kbar) or by the use of Lewis acid catalysts, allows the DielseAlder reaction to proceed in excellent yield and diastereoselectively to form cyclohexenyl-benzene cycloadducts, which are useful precursors for conicols. The successful total syntheses of conicol, epiconicol and didehydroconicol, are described.

A unified strategy for the synthesis of three conicol marine natural products

BARATTUCCI, Anna;BONACCORSI, Paola Maria;
2015-01-01

Abstract

A powerful, novel approach to meroterpenes conicol, epiconicol and didehydroconicol has been achieved via a key step DielseAlder reaction of (E)-3-methyl-1-(2’,5’ -dimethoxyphenyl)buta-1,3-diene as diene with methyl vinyl ketone, methyl acrylate or methyl propiolate as dienophiles. Activation by high pressure (9 kbar) or by the use of Lewis acid catalysts, allows the DielseAlder reaction to proceed in excellent yield and diastereoselectively to form cyclohexenyl-benzene cycloadducts, which are useful precursors for conicols. The successful total syntheses of conicol, epiconicol and didehydroconicol, are described.
2015
File in questo prodotto:
File Dimensione Formato  
TETRAHEDRON2015.pdf

solo utenti autorizzati

Tipologia: Versione Editoriale (PDF)
Licenza: Tutti i diritti riservati (All rights reserved)
Dimensione 552.88 kB
Formato Adobe PDF
552.88 kB Adobe PDF   Visualizza/Apri   Richiedi una copia
Pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11570/3094955
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 28
  • ???jsp.display-item.citation.isi??? 23
social impact