What is known and objective: Etoricoxib is a non-steroidal antiinflammatory drug (NSAID) that inhibits the inducible cyclooxygenase (COX-2) with a good safety profile. We describe the first case of two mucosal adverse events to etoricoxib in the same patient. Case description: Our patient developed stomatitis with mucosal exfoliation after etoricoxib assumption. Some months later, after a new etoricoxib intake, she presented with vaginal burning, tongue angioedema and erosions, oral exfoliation and wheals on the hands. A provocation test with diclofenac was negative. What is new and conclusion: The peculiarities of our case are the rare clinical manifestation and the selective hypersensitivity to COX-2 inhibitor with tolerance to a non-selective NSAID.
Mucosal exfoliation as a selective reaction to etoricoxib
PATANE', MASSIMOPrimo
;GANGEMI, Sebastiano;MINCIULLO, PAOLA LUCIA
Ultimo
2016-01-01
Abstract
What is known and objective: Etoricoxib is a non-steroidal antiinflammatory drug (NSAID) that inhibits the inducible cyclooxygenase (COX-2) with a good safety profile. We describe the first case of two mucosal adverse events to etoricoxib in the same patient. Case description: Our patient developed stomatitis with mucosal exfoliation after etoricoxib assumption. Some months later, after a new etoricoxib intake, she presented with vaginal burning, tongue angioedema and erosions, oral exfoliation and wheals on the hands. A provocation test with diclofenac was negative. What is new and conclusion: The peculiarities of our case are the rare clinical manifestation and the selective hypersensitivity to COX-2 inhibitor with tolerance to a non-selective NSAID.File | Dimensione | Formato | |
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Patan-_et_al-2016-Journal_of_Clinical_Pharmacy_and_Therapeutics.pdf
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