Osteoporotic related fractures are associated with increased disability and mortality rates. Poor muscle strength predicts falls and fractures. To promote early diagnosis of osteoporosis we screened all the postmenopausal women referring to our Centre during the World Osteoporosis Day in October 2012. Eighty-six subjects (mean age 61.2±8.7) were screened by a personal interview focused on clinical risk factors (CRFs), and the risk of major osteoporotic and hip fractures over ten years was estimated using the online version of the FRAX algorithm. Phalangeal quantitative ultrasound (QUS) and handgrip, which are indicators of bone and muscle strength respectively, were also evaluated and correlated to fracture risk. A DBM Sonic Bone Profiler (Igea, Carpi, Italy) was used to measure bone mass and a specific software automatically calculated the following QUS parameters: Amplitude Dependent Speed of Sound (AD-SoS); Ultrasound Bone Profile Index (UBPI) and T-Score. Handgrip was measured by Martin Dynamometer. Women were divided into three groups according to age. The median risk of major osteoporotic fracture (%) in the whole population was 6.3 (3.6-10) and the risk of hip fractures was 1.05 (0.4-3). Women over 65 years were found to be at higher fracture risk in comparison with subjects under 55 years and aged 55 to 65 years: their risk of major and hip fractures was 12 (8.05-19) and 3.9 (1.8-10.5) respectively; they showed also the poorer QUS values (AD-SoS: 1745.14119.68; UBPI: 0.170.11; T-score: -5.451.7). Handgrip was reduced in women over 65 years in comparison with women under 55 (19.474.29 vs. 23.17±6.83 Kg, p<0.05). QUS and handgrip values were both significantly inversely related to fracture risk evaluated by FRAX tool (p<0.05). QUS and handgrip could be clinically useful in association to FRAX to select women at risk for fracture suggesting further investigations, finally reducing social costs.

HANDGRIP STRENGHT AND PHALANGEAL QUANTITATIVE ULTRASOUND IN THE FRACTURE RISK ASSESSMENT OF POSTMENOPAUSAL WOMEN

CATALANO, ANTONINO;MORABITO, Nunziata;PAPALIA, MARIA;SCHEPISI, ROBERTO;MORINI, ELISABETTA;BASILE, Giorgio;LASCO, Antonino
2013-01-01

Abstract

Osteoporotic related fractures are associated with increased disability and mortality rates. Poor muscle strength predicts falls and fractures. To promote early diagnosis of osteoporosis we screened all the postmenopausal women referring to our Centre during the World Osteoporosis Day in October 2012. Eighty-six subjects (mean age 61.2±8.7) were screened by a personal interview focused on clinical risk factors (CRFs), and the risk of major osteoporotic and hip fractures over ten years was estimated using the online version of the FRAX algorithm. Phalangeal quantitative ultrasound (QUS) and handgrip, which are indicators of bone and muscle strength respectively, were also evaluated and correlated to fracture risk. A DBM Sonic Bone Profiler (Igea, Carpi, Italy) was used to measure bone mass and a specific software automatically calculated the following QUS parameters: Amplitude Dependent Speed of Sound (AD-SoS); Ultrasound Bone Profile Index (UBPI) and T-Score. Handgrip was measured by Martin Dynamometer. Women were divided into three groups according to age. The median risk of major osteoporotic fracture (%) in the whole population was 6.3 (3.6-10) and the risk of hip fractures was 1.05 (0.4-3). Women over 65 years were found to be at higher fracture risk in comparison with subjects under 55 years and aged 55 to 65 years: their risk of major and hip fractures was 12 (8.05-19) and 3.9 (1.8-10.5) respectively; they showed also the poorer QUS values (AD-SoS: 1745.14119.68; UBPI: 0.170.11; T-score: -5.451.7). Handgrip was reduced in women over 65 years in comparison with women under 55 (19.474.29 vs. 23.17±6.83 Kg, p<0.05). QUS and handgrip values were both significantly inversely related to fracture risk evaluated by FRAX tool (p<0.05). QUS and handgrip could be clinically useful in association to FRAX to select women at risk for fracture suggesting further investigations, finally reducing social costs.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11570/3096977
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