The remarkable affinity of deca-carboxylatopillar[5] arene WP5 towards the aminoglycoside antibiotic, amikacin, in aqueous media is reported; in vitro studies on Gram-positive bacteria (Staphylococcus aureus) show that drug entrapment inside WP5 also takes place in the presence of the microrganisms, thus pointing to WP5 as an appealing carrier for amikacin targeted delivery.

A water-soluble pillar[5]arene as a new carrier for an old drug

FRANCO, DOMENICO
Secondo
;
DE PLANO, LAURA MARIA;GATTUSO, Giuseppe;GUGLIELMINO, Salvatore;Lentini, Germana;MANGANARO, NADIA;PARISI, Melchiorre;PUNTORIERO, Fausto;PISAGATTI, Ilenia
Penultimo
;
NOTTI, Anna
Ultimo
2017-01-01

Abstract

The remarkable affinity of deca-carboxylatopillar[5] arene WP5 towards the aminoglycoside antibiotic, amikacin, in aqueous media is reported; in vitro studies on Gram-positive bacteria (Staphylococcus aureus) show that drug entrapment inside WP5 also takes place in the presence of the microrganisms, thus pointing to WP5 as an appealing carrier for amikacin targeted delivery.
2017
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11570/3106351
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