Curcumin has been shown to have a wide variety of therapeutic effects, ranging from anti-inflammatory, chemopreventive, anti-proliferative, and anti-metastatic. This review provides an overview of the recent research conducted to overcome the problems with the bioavailability of curcumin, and of the preclinical and clinical studies that have reported success in combinatorial strategies coupling curcumin with other treatments. Research on the signaling pathways that curcumin treatment targets shows that it potently acts on major intracellular components involved in key processes such as genomic modulations, cell invasion and cell death pathways. Curcumin is a promising molecule for the prevention and treatment of cancer.

Anticancer Activity of Curcumin and Its Analogues: Preclinical and Clinical Studies

ALLEGRA, Alessandro
Primo
;
INNAO, Vanessa;RUSSO, SABINA;GERACE, DEMETRIO GABRIELE;ALONCI, Andrea;MUSOLINO, Caterina
Ultimo
2017-01-01

Abstract

Curcumin has been shown to have a wide variety of therapeutic effects, ranging from anti-inflammatory, chemopreventive, anti-proliferative, and anti-metastatic. This review provides an overview of the recent research conducted to overcome the problems with the bioavailability of curcumin, and of the preclinical and clinical studies that have reported success in combinatorial strategies coupling curcumin with other treatments. Research on the signaling pathways that curcumin treatment targets shows that it potently acts on major intracellular components involved in key processes such as genomic modulations, cell invasion and cell death pathways. Curcumin is a promising molecule for the prevention and treatment of cancer.
2017
File in questo prodotto:
File Dimensione Formato  
Curcumin.pdf

solo utenti autorizzati

Descrizione: Articolo principale formato elettronico
Tipologia: Versione Editoriale (PDF)
Licenza: Tutti i diritti riservati (All rights reserved)
Dimensione 975.4 kB
Formato Adobe PDF
975.4 kB Adobe PDF   Visualizza/Apri   Richiedi una copia
3106435.pdf

solo utenti autorizzati

Descrizione: Articolo principale formato stampa
Tipologia: Versione Editoriale (PDF)
Licenza: Tutti i diritti riservati (All rights reserved)
Dimensione 715.3 kB
Formato Adobe PDF
715.3 kB Adobe PDF   Visualizza/Apri   Richiedi una copia
Pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11570/3106435
Citazioni
  • ???jsp.display-item.citation.pmc??? 45
  • Scopus 178
  • ???jsp.display-item.citation.isi??? 162
social impact