Sepsis represents amajor clinical problem in neonatal setting with elevated mortality rate related to multiple organ failure. Despite decades of research, the exact mechanism of organ failure in sepsis is still not completely understood. Oxidative stress (OS), derived from an imbalance between pro-oxidant and antioxidant factors, is involved in the pathogenesis of several neonatal diseases, including sepsis, and plays a particular role in systemic organ failure. Recently, it has been recognized that administration of antioxidants could be useful in septic patients. Among all antioxidants, melatonin has a characteristic role as an antioxidant, anti-inflammatory, and anti-apoptotic agent. In combination with other interventions, melatonin may contribute to an improvement in septic organ injury. Furthermore, melatonin has already been widely used in treating various diseases of neonatal population, including asphyxia, respiratory distress, and sepsis, and no significant toxicity or treatment-related side effects with long-term melatonin therapy have been reported. This review aims to summarize current knowledge concerning the potential beneficial role of melatonin in septic neonates, supporting its short-term adjuvant cotherapy to reduce complications during neonatal sepsis.

Melatonin and Neonatal Sepsis: A Promising Antioxidant Adjuvant Agent

D'angelo, Gabriella
Primo
;
Marseglia, Lucia;Gitto, Eloisa
Ultimo
2017-01-01

Abstract

Sepsis represents amajor clinical problem in neonatal setting with elevated mortality rate related to multiple organ failure. Despite decades of research, the exact mechanism of organ failure in sepsis is still not completely understood. Oxidative stress (OS), derived from an imbalance between pro-oxidant and antioxidant factors, is involved in the pathogenesis of several neonatal diseases, including sepsis, and plays a particular role in systemic organ failure. Recently, it has been recognized that administration of antioxidants could be useful in septic patients. Among all antioxidants, melatonin has a characteristic role as an antioxidant, anti-inflammatory, and anti-apoptotic agent. In combination with other interventions, melatonin may contribute to an improvement in septic organ injury. Furthermore, melatonin has already been widely used in treating various diseases of neonatal population, including asphyxia, respiratory distress, and sepsis, and no significant toxicity or treatment-related side effects with long-term melatonin therapy have been reported. This review aims to summarize current knowledge concerning the potential beneficial role of melatonin in septic neonates, supporting its short-term adjuvant cotherapy to reduce complications during neonatal sepsis.
2017
File in questo prodotto:
File Dimensione Formato  
Melatonin and Neonatal Sepsis.pdf

solo utenti autorizzati

Descrizione: PDF versione elettronica
Tipologia: Versione Editoriale (PDF)
Licenza: Tutti i diritti riservati (All rights reserved)
Dimensione 118.36 kB
Formato Adobe PDF
118.36 kB Adobe PDF   Visualizza/Apri   Richiedi una copia
3107385.pdf

solo utenti autorizzati

Descrizione: Articolo principale formato stampa
Tipologia: Versione Editoriale (PDF)
Licenza: Tutti i diritti riservati (All rights reserved)
Dimensione 3.2 MB
Formato Adobe PDF
3.2 MB Adobe PDF   Visualizza/Apri   Richiedi una copia
Pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11570/3116859
Citazioni
  • ???jsp.display-item.citation.pmc??? 9
  • Scopus 18
  • ???jsp.display-item.citation.isi??? 16
social impact