Antibiotic resistance: where are we going?

Antibiotic resistance represents the greatest threat in the field of infectious diseases today, due to the sharp increase of this event both in Europe and the World. The presence of these multidrug-resistant microorganisms in hospitals is associated with many risks, including the increased likelihood of treatment failure, an increased risk of morbidity and mortality, longer hospital stay, higher hospitalization costs and more legal disputes. The epidemiology of multidrug-resistant microorganisms infections varies from year to year, by geographical area, by hospital and by ward or department. Italy lies in fifth place among European countries regarding the use of antibiotics in human and veterinary clinical practice. Unfortunately, antibiotic resistance remains one of the highest in Europe and is consistently above the European average for both Gram negative and positive bacteria. The appearance and the growth of resistance to Carbapenems has been rapid, alarming and dramatic in Italy so much that the country is now classified as hyperendemic. It is important to highlight the known and emerging risk factors to define multidrug-resistant microorganisms prevention and control measures, both at individual and community level.